 |
|
|
|
Dr. John Hay
Microbiology and Immunology
211 Biomedical Research Building
Buffalo NY, 14214
Phone: (716) 829-2907
Email: jhay@buffalo.edu
 View map |
DESCRIPTION OF INTERESTS
-There are two main research interests in the Hay lab:
1. Varicella zoster virus (VZV)
This human virus causes chickenpox and shingles, but we have no clear idea of the mechanisms through which disease is caused. Our work focuses on a molecular approach to these mechanisms. For example, we have identified sequences in the promoter of the major viral gene regulatory protein which on the one hand allow the protein to be expressed only in neural cells and on the other hand allow self-regulation of transcription. In collaborative work with colleagues at Stanford University, we have shown that the major transactivator protein is a strong T-cell immunogen; this could be a candidate for a novel VZV vaccine.
2. Chronic Fatigue Syndrome (CFS)
This is a debilitating disease that adversely affects perhaps 5% of the US population. At present there is no evidence to suggest a specific cause for the disease. We have investigated the possibility that certain lymphotropic human viruses may be involved, and shown that neither HHV-6 nor HHV-7 appear to be direct candidates. However, a current hypothesis is that these viruses might induce cytokines that dispose to fatigue and we are looking in vivo and in vitro for evidence of cytokine appearance after virus infection. |
EDUCATION
| 1966 |
Doctor of Philosophy, Virology
Glasgow University
|
| 1963 |
Bachelor of Science, Biochemistry
Glasgow University
Magna Cum Laude
|
PUBLICATIONS
| Ruyechan W, Peng, H., Yang, M., Hay J; Cellular factors and IE62 activation of VZV promoters; J. Med. Virol.; 2003 Jan; |
| Ito, H., Sommer, M.H., Zerboni, L., He, H., Boucaud, D., Hay J, Ruyechan W, Arvin, A.M.; Promoter sequences of varicella-zoster virus glycoprotein 1 targeted by cellular transcription factors Sp1 and USF determine virulence in skin and T cells in SCIDhu mice in vivo; J. Virol.; 2003 Jan; 77; 489-498 |
| Arvin, A.M., Sharp, M., Moir, M., Kinchington, P.E., Sadeghi-Zadah, M., Ruyechan W, Hay J; Memory cytotoxic T cell responses to viral tegument and regulatory proteins encoded by open reading frames 4, 10, 29, and 62 of varicella zoster virus; Viral Immunology; 2002 Jan; 15; 507-516 |
| Lynch, J.M., Kenyon, T.K., Grose, C., Hay J, Ruyechan W; Physical and functional interaction between the varicella zoster virus IE63 and IE62 proteins; Virology; 2002 Jan; 302; 71-82 |
| Sommer MH, Zagha E, Serrano OK, Ku CC, Zerboni L, Baiker A, Santos R, Spengler M, Lynch J, Grose C, Ruyechan W, Hay J, Arvin AM; Mutational analysis of the repeated open reading frames, ORFs 63 and 70 and ORFs 64 and 69, of varicella-zoster virus.; J Virol; 2001 Sep; 75(17); 8224-8239 |
| Kenyon TK, Lynch J, Hay J, Ruyechan W, Grose C; Varicella-zoster virus orf47 protein serine kinase: characterization of a cloned, biologically active phosphotransferase and two viral substrates, orf62 and orf63.; J Virol; 2001 Sep; 75(18); 8854-8858 |
| He, H., Boucaud, D., Hay J, Ruyechan W; Cis and trans elements regulating expression of the varicella zoster virus gl gene; Arch. Virol.; 2001 Jan; 17; S57-S70 |
| Spengler, M., Ruyechan W, Hay J; Interactions among structural proteins of varicella zoster virus; Arch. Virol.; 2001 Jan; 17; S71-S79 |
| Sommer, M.H., Zagha, E., Serrano, O.K., Ku, C.C., Zerboni, L., Baiker, A., Santos, R., Spengler, M., Lynch, J., Grose, C., Ruyechan W, Hay J, Arvin, A.M.; Mutational analysis of the repeated open reading frames ORFs 63 and 70 and ORFs 64 and 69 of varicella zoster virus; J. Virol.; 2001 Jan; 75; 8224-8239 |
| Santos, R.A., Hatfield, C.C., Faga, B.P., Padilla, J.A., Cole, N.L., Moffat, J.F., Arvin, A.M., Spengler, M., Ruyechan W, Hay J, Grose, C.; Varicella zoster virus gE escape mutant VZV-MSP exhibits a novel genotype with an accelerated cell-to-cell spread phenotype in both infected cell cultures and SCID-hu mice; Virology; 2001 Jan; 75; 8224-8239 |
| Kenyon, T.K., Lynch, J., Hay J, Ruyechan W, Grose, C.; Varicella-zoster virus ORF47 protein kinase: characterization of a cloned, biologically active phosphotransferase and its viral substrates the ORF62 and ORF63 proteins; J. Virol.; 2001 Jan; 75; 8854-8858 |
| William Ruyechan, John Hay; VZV DNA replication; Varicella Zoster Virus; 2001 Jan; |
| Santos RA, Hatfield CC, Cole NL, Padilla JA, Moffat JF, Arvin AM, William Ruyechan, Hay J, Grose C; Varicella-zoster virus gE escape mutant VZV-MSP exhibits an accelerated cell-to-cell spread phenotype in both infected cell cultures and SCID-hu mice.; Virology; 2000 Sep; 275(2); 306-317 |
| Spengler ML, William Ruyechan, Hay J; Physical interaction between two varicella zoster virus gene regulatory proteins, IE4 and IE62.; Virology; 2000 Jul; 272(2); 375-381 |
| Ruyechan W, Hay J; Varicella Zoster Virus: DNA Replication; Varicella Zoster virus: virology and clinical management; 2000 Jan; |
| Teach SJ, Wallace HL, Evans MJ, Duffner PK, Hay J, Faden HS; Human herpesviruses types 6 and 7 and febrile seizures.; Pediatr Neurol; 1999 Oct; 21(4); 699-703 |
| Boulton M, Flessner M, Armstrong D, Mohamed R, Hay J, Johnston M; Contribution of extracranial lymphatics and arachnoid villi to the clearance of a CSF tracer in the rat.; Am J Physiol; 1999 Mar; 276(3 Pt); 818-823 |
| Wallace HL, Natelson B, Gause W, Hay J; Human herpesviruses in chronic fatigue syndrome.; Clin Diagn Lab Immunol; 1999 Mar; 6(2); 216-223 |
| Teach, S.J., Wallace, H., Evans, M.J., Duffner, P.K., John Hay, Faden, H.; HHV-6 and HHV-7 in children with febrile convulsions; Pediatric Neurol.; 1999 Jan; 21; 699-703 |
| Wallace, H., Natelson, B., Gause, W., John Hay; Human herpesviruses in chronic fatigue syndrome; Clin. Diag. Lab. Immunol.; 1999 Jan; 6; 216-223 |
| Applegate, K.L., John Hay, Cacioppo, J.T., Kiecolt-Claser, J.K., Glaser, R.; The effects of stress on the immune system - implications for reactivation of latent herpesviruses; Psychoneuroimmunology; 1999 Jan; |
| William Ruyechan, John Hay; Varicella zoster virus: molecular biology; Encyclopedia of Virology; 1999 Jan; |
| Boucaud D, Yoshitake H, Hay J, William Ruyechan; The varicella-zoster virus (VZV) open-reading frame 29 protein acts as a modulator of a late VZV gene promoter.; J Infect Dis; 1998 Nov; 178 S; 34-38 |
| Natelson BH, LaManca JJ, Denny TN, Vladutiu A, Oleske J, Hill N, Bergen MT, Korn L, Hay J; Immunologic parameters in chronic fatigue syndrome, major depression, and multiple sclerosis.; Am J Med; 1998 Sep; 105(3A); 43-49 |
| Natelson, B., LaManca, J., Denny, T., Vladutiu, A., Oleske, J., Hill, N., Bergen, Korn, L., John Hay; Immunological parameters in chronic fatigue syndrome, major depression and multiple sclerosois; Am. J. Med.; 1998 Jan; 105; 7S-10S |
| Zhao, X., John Hay; The epidemiology of hantavirus infections; Clin. Microbiol. Newsletter; 1997 Jan; 19; 49-52 |
| John Hay; Vaccinia, vaccination, vaccinology: Jenner, Pasteur and their successors; Clin. Inf. Dis.; 1997 Jan; 24; 49-52 |
| Stevenson D, Xue M, Hay J, William Ruyechan; Phosphorylation and nuclear localization of the varicella-zoster virus gene 63 protein.; J Virol; 1996 Jan; 70(1); 658-662 |
| Zhao, X., John Hay; The evolution of hantaviruses; Immun. Invest.; 1996 Jan; 26; 191-198 |
| Kantakamalakul W, William Ruyechan, Hay J; Analysis of varicella-zoster virus promoter sequences.; Neurology; 1995 Dec; 45(12 Su); 28-29 |
| Maheshwari, R.K., Sidhu, G.S., Singh, A.K., Sivaram, S.S., Kinchington, P.R., John Hay, Friedman, R.M.; Defective transport of HSV-1 glycoprotein in interferon-treated cells: role of intracellular pH; J. Interferon Res.; 1995 Jan; 14; 319-324 |
| John Hay, Arvin, A.M.; Proceedings of the Second VZVRF Conference, Bethesda, MD; Annals of Neurology; 1994 Jan; 35; S1-S72 |
| John Hay, William Ruyechan; Varicella zoster virus; Seminars in Virology; 1994 Jan; 5; 241-247 |
| Hay J, Ruyechan W; Varicella zoster virus - a different kind of herpesvirus latency?; Seminars in Virology; 1994 Jan; 5; 241-247 |
| John Hay, William Ruyechan; Varicella zoster virus-a different kind of herpesvirus latency?; Virology; 1994 Jan; 5; 241-247 |
| Ruyechan W, Hay J; Varicella zoster virus: Molecular Biology; Encyclopedia of Virology; 1994 Jan; 2; 1518-1527 |
| William Ruyechan, John Hay; Varicella zoster; molecular biology; Encyclopedia of Virology; 1994 Jan; 2; 1518-1527 |
| Sabella C, Lowry PW, Abbruzzi GM, Koropchak CM, Kinchington PR, Sadegh-Zadeh M, Hay J, William Ruyechan, Arvin AM; Immunization with the immediate-early tegument protein (open reading frame 62) of varicella-zoster virus protects guinea pigs against virus challenge.; J Virol; 1993 Dec; 67(12); 7673-7676 |
| Perera LP, Mosca JD, William Ruyechan, Hayward GS, Straus SE, Hay J; A major transactivator of varicella-zoster virus, the immediate-early protein IE62, contains a potent N-terminal activation domain.; J Virol; 1993 Aug; 67(8); 4474-4483 |
| John Hay, Jenkins, F.J.; Herpesviruses; Chronic Fatigue Syndrome; 1993 Jan; |
| Perera LP, Mosca JD, Sadeghi-Zadeh M, William Ruyechan, Hay J; The varicella-zoster virus immediate early protein, IE62, can positively regulate its cognate promoter.; Virology; 1992 Nov; 191(1); 346-354 |
| Pensiero MN, Sharefkin JB, Dieffenbach CW, Hay J; Hantaan virus infection of human endothelial cells.; J Virol; 1992 Oct; 66(10); 5929-5936 |
| Perera LP, Mosca JD, William Ruyechan, Hay J; Regulation of varicella-zoster virus gene expression in human T lymphocytes.; J Virol; 1992 Sep; 66(9); 5298-5304 |
| Ling P, Kinchington PR, Sadeghi-Zadeh M, William Ruyechan, Hay J; Transcription from varicella-zoster virus gene 67 (glycoprotein IV).; J Virol; 1992 Jun; 66(6); 3690-3698 |
| Sharp M, Terada K, Wilson A, Nader S, Kinchington PE, William Ruyechan, Hay J, Arvin AM; Kinetics and viral protein specificity of the cytotoxic T lymphocyte response in healthy adults immunized with live attenuated varicella vaccine.; J Infect Dis; 1992 May; 165(5); 852-858 |
| Lowry PW, Solem S, Watson BN, Koropchak CM, Thackray HM, Kinchington PR, William Ruyechan, Ling P, Hay J, Arvin AM; Immunity in strain 2 guinea-pigs inoculated with vaccinia virus recombinants expressing varicella-zoster virus glycoproteins I, IV, V or the protein product of the immediate early gene 62.; J Gen Virol; 1992 Apr; 73 (; 811-819 |
| Pensiero MN, Hay J; The Hantaan virus M-segment glycoproteins G1 and G2 can be expressed independently.; J Virol; 1992 Apr; 66(4); 1907-1914 |
| John Hay, William Ruyechan; Expression and function of herpes simplex virus gene products; The Immunobiology of Herpes Simplex Infections; 1992 Jan; |
| John Hay, William Ruyechan; Regulation of herpes simplex virus Type 1 gene expression; Current Topics in Microbiol. and Immunol.; 1992 Jan; 179; 1-14 |
| Ruyechan W, Hay J; Regulation of herpes simplex virus type 1 gene expression; The Immunobiology of Herpes Simplex Infections; 1992 Jan; |
| Kinchington PR, Hougland JK, Arvin AM, Ruyechan WT, Hay J; The varicella-zoster virus immediate-early protein IE62 is a major component of virus particles.; J Virol; 1992 Jan; 66(1); 359-366 |
| Ling P, Kinchington PR, Ruyechan WT, Hay J; A detailed analysis of transcripts mapping to varicella zoster virus gene 14 (glycoprotein V).; Virology; 1991 Oct; 184(2); 625-635 |
| Arvin AM, Sharp M, Smith S, Koropchak CM, Diaz PS, Kinchington P, Ruyechan W, Hay J; Equivalent recognition of a varicella-zoster virus immediate early protein (IE62) and glycoprotein I by cytotoxic T lymphocytes of either CD4+ or CD8+ phenotype.; J Immunol; 1991 Jan; 146(1); 257-264 |
| Kinchington, P.R., William Ruyechan, John Hay; Herpesvirus vaccines; Vaccines and Immunotherapy; 1991 Jan; |
| Kinchington, P.R., Ruyechan W, Hay J; Herpesvirus vaccines; Vaccines and Immunotherapy, The Swiss Vaccine Institute; 1991 Jan; |
| Ruyechan W, Ling, P., Kinchington, P.R., Hay J; The correlation between varicella-zoster virus transcription and the sequence of the viral genome; Herpesvirus Transcription and Its Regulation; 1991 Jan; |
| Kinchington, P.R., Ling, P., Pensiero, M., Gershon, A., Hay J, Ruyechan W; A possible role for glycoprotein gpV in the pathogenesis of varicella-zoster virus; Adv. Exptl. Med. Biol.; 1990 Jan; 278; 83-91 |
| Kinchington, P.R., Ling, P., Pensiero, M., Gershon, A., John Hay, William Ruyechan; A possible role for glycoprotein gpV in the pathogenesis of varicella-zoster virus; Advances in Exp. Med. Biol.; 1990 Jan; 278; 83-91 |
| Kinchington, P.R., Ling, P., Pensiero, M., Gershon, A., John Hay, William Ruyechan; A possible role for glycoprotein gpV in the pathogenesis of varicella-zoster virus; Immunobiology and Prophylaxis of Human Herpesvirus Infections; 1990 Jan; |
| Feuerstein, N., Mond, J., Kinchington, P.R., Hickey, R., Lindsbert, M.-L., John Hay, William Ruyechan; Evidence for DNA binding activity of numatrin (B23), a cell cycle-regulated nuclear matrix protein; Biochem. Biophys. Acta.; 1990 Jan; 1087; 127-136 |
| William Ruyechan, Ling, P., Kinchington, P.R., John Hay; The correlation between varicella zoster virus transcription and the sequence of the viral genome; Herpesvirus Transcription and Its Regulation; 1990 Jan; |
| Kinchington, P.R., Ling, P., Pensiero, M., Moss, B., William Ruyechan, John Hay; The glycoprotein products of varicella-zoster virus gene 14 and their defective accumulation in a vaccine strain (Oka); J. Virol.; 1990 Jan; 64; 4540-4548 |
| Morokoff, P.J., Myers, L., John Hay, Flora, M.M.; Effectiveness of a procedure for disinfecting the vaginal photoplethysmograph contaminated with herpes simplex virus type 2; Arch. Sex. Behavior; 1988 Jan; 17; 363-369 |
| Pensiero, M.N., Jennings, G.B., Schmaljohn, C.S., John Hay; Expression of the Hantaan virus M genome segment by using a vaccinia virus recombinant; J. Virol.; 1988 Jan; 62; 696-702 |
| Kinchington, P.R., Inchuaspe, G., Subak-Sharpe, J.H., Robey, F., John Hay, William Ruyechan; Identification and characterization of a varicella-zoster virus DNA-binding protein by using antiseera directed against a predicted synthetic oligopeptide; J. Virol.; 1988 Jan; 62; 802-809 |
| John Hay, Roberts, C.R., William Ruyechan, Steven, A.C.; Herpesviridae; Animal Virus Structure; 1987 Jan; |
| Schmaljohn, C.S., Jennings, G.B., John Hay, Dalrymple, J.M.; Coding strategy of the S genome segment of Hantaan virus; Virology; 1986 Jan; 155; 633-643 |
| Steven, A.C., Roberts, C.R., John Hay, Bisher, M., Pun, T., Trus, B.; Hexavalent capsomers of herpes simplex virus type 2: Symmetry, shape, dimensions and oligomeric status; J. Virol.; 1986 Jan; 57; 578-584 |
| Kinchington, P.R., Remenick, J., Ostrove, J.M., Straus, S.E., William Ruyechan, John Hay; Putative glycoprotein gene of varicella-zoster virus with variable copy numbers of a 42-base- pair repeat sequence has homology to herpes simplex virus glycoprotein C.; J. Virol.; 1986 Jan; 59; 660-669 |
| Ostrove, J.M., Reinhold, W., Fan, C.-M., Zorn, S., John Hay, Straus, S.E.; Transcription mapping of the varicella-zoster virus genome; J. Virol.; 1986 Jan; 56; 600-606 |
| William Ruyechan, Casey, T.A., Reinhold, W., Weir, A.C., Wellman, M., Straus, S.E., John Hay; Distribution of G+C-rich regions in varicella-zoster virus DNA; J. Gen. Virol.; 1985 Jan; 66; 43-54 |
| Roberts, C.R., Weir, A.C., John Hay, Straus, S.E., William Ruyechan; DNA-binding proteins present in varicella-zoster virus-infected cells; J. Virol.; 1985 Jan; 55; 45-53 |
| Casey, T.A., William Ruyechan, Flora, M.N., Reinhold, W., Straus, S.E., John Hay; Fine mapping and sequencing of a variable setment in the inverted repeat region of varicella zoster virus DNA; J. Virol.; 1985 Jan; 54; 639-642 |
| Kinchington, P.R., Reinhold, W.C., Casey, T.A., Straus, S.E., John Hay, William Ruyechan; inversion and circularization of the varicella zoster virus genome; J. Virol.; 1985 Jan; 56; 194-200 |
| Wohlrab, F., Jamieson, A.T., John Hay, Mengel, R., Guschlbauer, W.; the effect of 2'-fluoro-2'-deoxycytidine on herpes virus growth; Biochem. Biophys.; 1985 Jan; 824; 233-242 |
| Ruyechan W, Casey, T.A., Reinhold, W., Weir, A.C., Wellman, M., Straus, S.E., Hay J; Distribution of G+C-rich regions in varicella zoster virus DNA; J. Gen. Virol.; 1984 Jan; 66; 43-54 |
| Straus, S.E., Reinhold, W., Smith, H.A., William Ruyechan, Henderson, D.K., Blaese, R.M., John Hay; Endonuclease analysis of viral DNA from varicella and subsequent zoster infections in the same patient; N. Engl. J. Med.; 1984 Jan; 311; 1362-1364 |
| Wathen, M.W., John Hay; Physical mapping of the herpes simplex virus type 2 nuc lesion affecting alkaline exonuclease activity by using herpes simplex virus type 1 deletion clones; J. Virol.; 1984 Jan; 51; 237-241 |
| Seidlein, M., Takiff, H.E., Smith, H.A., Straus, S.E., John Hay; Rapid diagnosis of varicella zoster virus infections by hybridization using a molecularly cloned viral DNA probe; J. Med. Virol.; 1984 Jan; 13; 53-61 |
| Straus, S.E., John Hay, Smith, H., Owens, J.; Genome differences among varicella zoster virus isolates; J. Gen. Virol.; 1983 Jan; 64; 1031-1041 |
| Rixon, F.J., Atkinson, M.A., John Hay; Intranuclear distribution of herpes simplex virus type 2 DNA synthesis: Examination by light and electron microscopy; J. Gen. Virol.; 1983 Jan; 64; 2087-2092 |
| Watson, R.J., John Hay; Herpesvirus structural components; Viruses Associated with Human Cancer; 1982 Jan; |
| Straus, S.E., Owens, J., William Ruyechan, Takiff, H., Casey, T.A., Vande Woude, G.F., John Hay; Molecular cloning and physical mapping of varicella zoster virus DNA; Proc. Nat. Acad. Sci. (Wash); 1982 Jan; 79; 993-997 |
| Maheshwari, R.K., Sreelvasen, T., Silverman, R.H., John Hay, Friedman, R.M.; tunicamycin treatment enhances the antiviral action of interferon; Science; 1982 Jan; 219; 1339-1341 |
| Hay, R.T., John Hay; Characteristics of chromatin preparations from herpes simplex virus infected cells; Biochem. Biophys. Acta; 1981 Jan; 655; 71-81 |
| Straus, S.E., Aulakh, H.S., William Ruyechan, John Hay, Casey, T.A., Vande Woude, G.F., Owens, J., Smith, H.A.; Structure of varicella zoster virus DNA; J. Virol.; 1981 Jan; 40; 516-525 |
| John Hay, Bartkoski, M.J.; Virus pathogenesis; Handbook of Molecular Pharmacology; 1981 Jan; 61; 1-94 |
| Hay, R.T., John Hay; Properties of herpesvirus-induced "immediate early" polypeptides; Virology; 1980 Jan; 104; 230-234 |
| McNab, J.C.M., Visser, L., Jamieson, A.T., John Hay; Virus antigens in cells transformed by herpes simplex virus; Cancer Res.; 1980 Jan; 40; 2074-2079 |
| Moss, H., Chartrand, R., Timbury, M.D., John Hay; A mutant of herpes simplex virus type 2 with temperature-sensitive lesions affecting virion thermolability and deoxyribonuclease activity: Identification of the lethal mutation and physical mapping of the nuc-lesion; J. Virol.; 1979 Jan; 32; 140-147 |
| Francke, B., Moss, H., Timbury, M.C., John Hay; Alkaline exonuclease activity in cells infected with a temperature-sensitive mutant of herpes simplex virus type 2; J. Virol.; 1978 Jan; 26; 209-213 |
| Hay, R.T., John Hay; Synthesis of herpes simplex virus DNA in preparations of chromatin from infected cell nuclei; J. Gen. Virol.; 1978 Jan; 41; 427-432 |
| Clements, J.B., John Hay; RNA and protein synthesis in herpesvirus-infected cells; J. Gen. Virol.; 1977 Jan; 35; 1-12 |
| John Hay, Brown, S.M., Jamieson, A.T., Rixon, F.J., Moss, H., Darjan, D.A., Subak-Sharpe, J.H.; The effect of phosphonoacetic acid on herpes viruses; J. Antimicrob. Chemother.; 1977 Jan; 3; 63-70 |
| John Hay, Moss, H., Jamieson, A.T., Timbury, M.; Herpesvirus proteins: DNA polymerase and pyrimidine deosynucleoside kinase activities in temperature-sensitive mutants of herpes simplex virus type 2; J. Gen. Virol.; 1976 Jan; 31; 65-73 |
| John Hay, Subak-Sharpe, H.; Mutants of herpes simplex virus types 1 and 2 that are resistant to phosphonoacetic acid induce altered DNA polymerase activities in infected cells; J. Gen. Virol.; 1976 Jan; 31; 145-148 |
| Jamieson, A.T., John Hay, Subak-Sharpe, H.; Phosphotransferase activity induced by herpes simplex virus; J. Virol.; 1976 Jan; 17; 1056-1059 |
| Subak-Sharpe, H., John Hay; Virus-induced enzymes; Proc. Int. Congress Chemotherapy; 1976 Jan; |
| Timbury, M.C., John Hay; Biochemical and genetic behavior of mutants of herpes simplex type 2; Herpesviruses and Oncogenesis; 1975 Jan; 86; 219-225 |
| Subak-Sharpe, J.H., John Hay, Timbury, M.C., Ritchie, D.A., Brown, S.M., Macnab, J.M., Marsden, J.S.; Genetic studies with herpes simplex virus; Cold Spr. Harb. Symp. Quant. Biol.; 1975 Jan; 39; 717-730 |
| Bayliss, G.J., Marsden, H.S., John Hay; Herpex simplex virus proteins: DNA-binding proteins in infected cells and in the virus structure; Virology; 1975 Jan; 68; 124-134 |
| Howard, D.K., John Hay, Melvin,W.T., Durham, J.P.; Changes in DNA and RNA synthesis and associated enzyme activities after the stimulation of serum-depleted BHK21/C13 cells by the addition of serum; Exptl. Cell Res.; 1974 Jan; 86; 31-42 |
| Tyler, Sheila, J., John Hay, Stevely, W.S.; The effect of pseudorabies virus infection on nuclear protein synthesis in hamster kidney cells; Arch. Ges. Virusforsch.; 1974 Jan; 44; 84-92 |
| Pringle, C.R., Howard, D.K., John Hay; Temperature-sensitive mutants of pseudorabies virus with differential effects on viral and host DNA synthesis; Virology; 1973 Jan; 55; 495-505 |
| John Hay, Perera, P.A.J., Morrison, J.M., Gentry, G.A., Subak-Sharpe, J.H.; Herpesvirus-specified proteins; Strategy of the Viral genome; 1971 Jan; |
| Jarrett, O., Pitts, J.D., Whalley, J.M., Clason, A.E., John Hay; Isolation of the nucleic acid of feline leukemia virus; Virology; 1971 Jan; 43; 317-320 |
| John Hay, Pillinger, D.J., Borek, E.; The effect of hypermethylation on the functional properties of transfer ribonucleic acid: II. Ribosome binding and polypeptide synthesis; Biochem. J.; 1970 Jan; 119; 587-593 |
| Low, M., John Hay, Keir, H.M.; DNA of herpes simplex virus is not a substrate for methylation in vivo; J. Molec. Biol.; 1969 Jan; 46; 205-207 |
| Pillinger, D.J., John Hay, Borek, E.; The effect of hypermethylation on the functional properties of transfer ribonucleic acid: Formation of aminoacyl-transfer-ribonucleic acid; Biochem. J.; 1969 Jan; 114; 429-435 |
| John Hay; the origin of viruses; Queen Elizabeth College Microbiology Soc. Journal; 1969 Jan; 1; 17-20 |
| Subak-Sharpe, H., John Hay; Analysis of nearest neighbour base frequencies in the RNA of a mammalian virus: Encephalomyocarditis virus; J. Gen. Virol.; 1968 Jan; 2; 469-472 |
| Keir, H.M., John Hay, Morrison, J.M., Subak-Sharpe, H.; Altered properties of deoxynucleic acid nucleotidyltransferase after infection of mammalian cells with herpes simplex virus; Nature; 1966 Jan; 210; 369-371 |
| Subak-Sharpe, H., Burk, R.R., Crawford, L.V., Morrison, J.M., John Hay, Keir, H.M.; An approach to evolutionary relationships of mammalian DNA viruses through analysis of the pattern of nearest neighbour base sequences; Cold Spr. Harb. Symp. Quant. Biol.; 1966 Jan; 31; 737-741 |
| John Hay, Koteles, G.J., Keir, H.M., Subak-Sharpe, H.; Herpes virus specified ribonucleic acids; Nature; 1966 Jan; 210; 387-390 |
| Subak-Sharpe, H., Shepherd, W.M., John Hay; Studies on sRNA coded by herpes virus; Cold Spr. Harb. Symp. Quant. Biol.; 1966 Jan; 31; 583-586 |
| Subak-Sharpe, H., John Hay; An animal virus with DNA of high guanine+cytosine content which codes for SRNA; J. Molec. Biol.; 1965 Jan; 12; 924-928 |
| He H, Boucaud D, John Hay, William Ruyechan; Cis and trans elements regulating expression of the varicella zoster virus gI gene.; Arch Virol Suppl; (17); 57-70 |
| Spengler M, Niesen N, Grose C, William Ruyechan, John Hay; Interactions among structural proteins of varicella zoster virus.; Arch Virol Suppl; (17); 71-79 |
| Zhao X, Hay J; The evolution of hantaviruses.; Immunol Invest; 26(1-2); 191-197 |
GRANTS
September 1999 to August 2004
Training in microbial pathogenesis
National Institutes of Health
Thomas Melendy, John Hay
$162,556
|
July 1999 to June 2004
Training in Microbial Pathogenesis
National Institute of Allergy and Infectious Diseases
John Hay, Noreen Williams
$856,496
|
|
|
|
|
|
|
|
|
|